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Conversely, patients with effective conventional treatment options available should generally pursue established therapies before considering investigational peptide approaches

We also established a policy to package the costs of the devices that are no longer eligible for pass-through ( payments into the costs of the procedures with which the devices are reported in the claims data used to set the payment rates (67 FR 66763)

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While, under this authority, we would ordinarily use the ASP methodology under section 1847A of the Act, we continued to find that the ASP data we had was not usable for payment purposes

Impaired bloodbrain and bloodspinal cord barriers in mutant SOD1-linked ALS rat