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Dosing recommendations are outside the educational content because they are incompatible with RUO positioning

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Metoclopramide demonstrates mixed results due to central nervous system side effects and limited upper gastrointestinal effectiveness [64]

Pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and NOD-like receptors (NLRs), sense microbial components and damage-associated molecular patterns (DAMPs), triggering activation of signaling cascades such as NF-B, MAPK, and inflammasomes (e.g., NLRP3), which further amplify the inflammatory response [40]