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Published findings concerning body composition, glucose regulation, liver pathology and muscle function come from laboratory and animal studies rather than established human clinical trials
Conclusions Coexisting pathologies can sometimes mask the obvious findings and mislead the diagnosis
Duration at different dose levels At 1mg weekly (titration start): 20mg / 1mg per week = 20 weeks from a single vial You would never use the entire vial at this dose since titration advances every 4 weeks
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The MHRA Drug Safety Update on metformin and reduced vitamin B12 levels advises that B12 testing should be considered in patients who are symptomatic or who have risk factors for deficiency