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This group probably "opens" disulfide linkages in mucus thereby lowering the viscosity

P53 phosphorylation at Ser15 was confirmed to enhance the affinity for both FOXO4 and FOXO4-DRI, providing a structural explanation for FOXO4-DRIs preferential engagement with the hyperphosphorylated p53 that characterises senescent cells

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Moreover, protection of unconjugated 3-OH group in the C-ring with catechol group by a large group (e.g., by glycosylation or alkylation) has been linked with no enzyme inhibition, as it has been noted for quercetin 3- O -glucoside 112