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Renal physiol

Further detail of the algorithm can be found in ESM Methods

Morbid obesity takes 10 years off your life expectancy

GLP-1 medications (semaglutide, tirzepatide) carry FDA boxed warnings related to thyroid C-cell tumors in rodent studies and are contraindicated in patients with a personal or family history of medullary thyroid cancer or MEN-2

From a purely molecular standpoint, there is no universal 'gentlest' option