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doi: 10.1039/c4fo00948g 16 CiceroA

All these observations on different uremic toxins were confirmed by in vitro studies: RBCs from healthy subjects were treated with different concentrations of the uremic toxins and at different time points

The intracellular concentration of gamma-glutamylcysteine (GGC) is extremely low (~ 5 uM) when GS is present, thus GCL is considered the rate-limiting enzyme [6]

(2023) 195:E1538

7 Over time, this results in significant damage to the cardiovascular and central nervous systems, including disrupting the blood brain barrier, inducing mitochondrial dysfunction, and damaging DNA

Some of the major conventional techniques for measuring aggregation of biopharmaceuticals include