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It is known that the insulin resistance (i.e., the insensitivity of cells, in particular, hepatocytes, skeletal muscle cells, and adipocytes to insulin, the primary hormone in glucose homeostasis in the fed state) predisposes to T2DM

For most people, that is Wegovy (semaglutide) is an FDA-approved medication that helps adults/teens manage their weight

GLP-1RAs have also been effective as an adjunct therapy (for example, in combination with nicotine replacement therapy)

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Yet, the narrow margin between deficiency and toxicity, modulated by edaphic and climatic factors, renders nutrient balance highly vulnerable