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An interesting approach involves using a cathepsin-cleavable valine-citrulline (Val-Cit) linker in a macromolecular prodrug platform for pulmonary intracellular infections, providing controlled drug release and enhanced antibacterial efficacy (Fig

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The chloroacetamide moiety embedded in the chemical structure of RSL3 and ML162 contributes to their GPX4 inhibitory activity [217]

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