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Raad H, Serrano-Sanchez M, Harfouche G, Mahfouf W, Bortolotto D, Bergeron V, et al

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TB-500 is a synthetic fragment of thymosin beta-4 (residues 1723, sequence Ac-LKKTETQ) studied for its role in actin sequestration and cytoskeletal organization specifically the regulation of G-actin to F-actin polymerization balance that governs cell morphology and migration

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Despite the positive results, due to the limited number of included studies, further randomized controlled trials are needed to investigate the safety and efficacy of SGLT2i and GLP-1RAs as first-line treatment options for patients with T2DM at low cardiovascular disease risk, particularly when compared to metformin