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Dilated fundus evaluation demonstrated notable optic disc edema, mostly concentrated superiorly/superonasally in the right eye (Figure 5)

The medical takeaway is simple: retatrutide is not just another celebrity weight-loss trend. It is part of a larger movement toward more powerful incretin-based therapies that may change how obesity, metabolic disease, and body composition are treated

While the specific mechanism causing the effects on the gastrointestinal tract are not fully elucidated, studies suggest GLP-1 and its analogues likely exert effects on the vagus nerve and inhibit cholinergic neurotransmission in the gastrointestinal system to prevent movement of the intestine

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