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However, the exact mechanisms underlying these effects remain unclear, particularly whether the cognitive improvements are a direct result of GLP-1 action or are mediated indirectly via enhanced glucose regulation

& Yuan, J

Vaciamiento gstrico ms lento: La semaglutida retrasa el vaciado del estmago, lo que estabiliza los niveles de glucosa despus de las comidas y refuerza la sensacin de saciedad

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In the Phase 2 trial protocol, participants reached the 12mg maximum dose at week 20 after five escalation steps (1mg, 2mg, 4mg, 8mg, 12mg), each held for four weeks

The metabolic sensors in these cells respond to glucose as described above, and GLP-1 treatment reversed the glucose effects [83]