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Alternative models: from humanized mice to microphysiological systems and beyond, in: Scientific and Regulatory Considerations for Assessment of Immunogenicity Risk for Generic Peptide and Oligonucleotide Drug Products at The Universities at Shady Grove, Rockville, MD (Day 2, Session 4),

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You often don't without ruling other things out first, which is the point of a provider assessment

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219 Restoring autophagic flux enables the selective degradation of ER fragments containing misfolded proteins and lipids via autolysosomes, a process known as reticulophagy, which can markedly alleviate ER stress and help restore ER function

Evidence Ledger: What Claims Actually Have Support