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The CagriSema combination (Cagrilintide + Semaglutide) has demonstrated up to 25% weight loss in Phase 3 research, establishing it as a critical compound for dual-mechanism metabolic studies

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Sipetic-Grujicicl S, Vlajinac H, Maksiniovic J, Marinkovic J, Dzoljic E, Ratkov I, Kostic V

In addition, the levels of Salicylic acid (SA) and Jasmonic acid (JA) increased significantly, the expression levels of the genes encoding transcription factor TGA (PG2023696), pathogenesis-related protein 1 (PR1) (PG0005111), and the transcription inhibitor Aux/IAA (PG0006093) all increased while the expression levels of jasmonate ZIM domain-containing protein (JAZ) (PG0004367), auxin influx carrier (AUX) (PG0006550) and auxin response factor (ARF) (PG0005794) all decreased