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The diabetes-licensed products (Ozempic, Rybelsus) operate at lower doses

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Effects: By activating GLP-1 receptors, Tirzepatide increases insulin secretion in response to meals, reduces glucagon release (which helps lower blood sugar), and slows gastric emptying (promoting feelings of fullness)

Stimulation of the PI3K/Akt/mTOR protein synthesis pathway: Upon receptor activation, IGF-1 LR3 triggers intracellular cascades including PI3K and Akt phosphorylation