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Nagayach A, Wang C

Vitamin C pharmacokinetics of plain and slow release formulations in smokers

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These findings will facilitate rational structure-based discovery of non-peptide agonists targeting class B GPCRs

The tert-butyl moiety of compound 2 points to TM7 and makes hydrophobic contacts with A350 6.39b and K351 6.40b , replacement at C-3 position by polar functional groups caused dramatic decline in its potency and efficacy 38

For doses under 20 units, a 0.3 mL or 0.5 mL syringe with 1-unit markings gives better precision than a 1 mL syringe marked in 2-unit steps