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83 Divalent ion deficiency Divalent ions such as Mg 2+ , Co 2+ , and Mn 2+ are activators of ALP, and Zn 2+ is a constituent metal ion of the enzyme

Although reported AEs are generally not serious and safety and efficacy in older adults are generally comparable to those in younger adults [36], higher AE rates may nonetheless predispose older adults to additional risks that are more critical in this population, such as hypoglycemia, dehydration, or impaired renal function

Consumers should check MHRA safety communications before purchasing weight loss products, particularly from online sources

Nature 434 , 113118 (2005)

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(Tirzepatide discovery) Willard FS, et al