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doi: 10.4103/0378-6323.179088

In support of this notion, normalization of SR calcium handling in animal models of heart failure (HF) has been shown to reduce the incidence of cardiac alternans and ventricular arrhythmias [25]

This process is driven by disrupted GSH homeostasis, resulting from diminished GSH synthesis and impaired activity of two critical antioxidant systems: (1) the cystine/glutamate antiporter xCT, which imports cystine to fuel GSH production and (2) GPX4, which utilizes GSH to convert lipid peroxides into less toxic lipid alcohols (Stockwell et al., 2017

diarrhea is typically secondary to conditions causing malabsorption (e.g., IBD, celiac) rather than B12 itself

ISRN Urol 2012

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