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Curr Pharm Des 20:11211125 Shibuya M (2011) Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) signaling in angiogenesis: a crucial target for anti- and pro-angiogenic therapies

Would require pharmaceutical development ensuring sterility, pH compatibility, osmolality, and lack of retinal toxicity

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It also reduced enteric serotonin release while suppressing intestinal motility

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