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Phase 3 Program: TRIUMPH Trials (20252026) The Phase 3 TRIUMPH investigational program is one of the most extensive registrational programs ever undertaken for a metabolic compound, with ongoing trials in obesity with comorbidities, type 2 diabetes, knee osteoarthritis, obstructive sleep apnea, chronic low back pain, cardiovascular outcomes, and MASLD

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Studies using APP/PS1 mouse models have shown that changes in gut microbiota composition can lead to higher levels of amyloid beta (A) in the central nervous system, as well as notable declines in memory and spatial learning abilities (132)

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Musial-Bright et al., 2011)