Useful for targeted dark areas These creams are often applied to specific areas such as the face, hands, feet, elbows, and knuckles where discoloration is more noticeable
Data are expressed as a fold relative to parental control (no dox, no BSO), and are derived from two individual replicates performed in triplicate with SD indicated
Friction-induced darkening often responds well to treatment, whilst genetic predisposition to darker skin may limit how much lightening is achievable
405 Cells were transiently transfected with CBS siRNA to probe the transcriptional regulation of sterol regulatory element binding protein (SREBP) (lipid transcription factor)
Pulling the threads together, the experimental literature does suggest a real functional distinction provided one keeps the honesty caveats in view
Lees Swedish study stands out for its rigor