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Source: NEJM 2023 Safety profile: The most common adverse events were gastrointestinal (nausea 58%, diarrhea 39%, vomiting 32% in the 12 mg group)

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Monocyte chemoattractant protein 1 (referred to in the figures as Ccl2 gene) is linked to proinflammatory states, and its renal expression was increased in diabetic mice ( p = 0.018 for diabetes as a factor) (Figure 3G)