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The rs12720356 (I684S) and rs3456443 (P1104A) have also been implicated in T1D and other autoimmune diseases, including psoriasis, rheumatoid arthritis, and Crohns disease (121)

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This can lead to: Puffy hands or feet Morning stiffness in the joints Mild carpal tunnel-like sensations Reducing the dose or spacing out injections may help minimize these symptoms

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Conforti, L., Gilley, J