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Management of acute kidney injury in symptomatic multiple myeloma

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Cohort 1 stratified ambulatory patients 521 years of age into two arms (apitegromab 20 mg/kg alone or in combination with nusinersen), cohort 2 evaluated apitegromab 20 mg/kg combined with nusinersen in non-ambulatory patients 521 years of age and cohort 3 randomized patients 2 years of age to apitegromab 2 mg/kg or 20 mg/kg in combination with nusinersen in a blinded manner

Cardiovascular risk markersincluding blood pressure, C-reactive protein, and atherosclerotic burdenalso inform provider recommendations

We consider first the time evolution of the tumour concentration

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