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A significant decreased of the GSH/GSSG ratio was observed following HC treatment (Figure 8D), suggesting an impairment of the cellular reducing capacity and a shift toward a more oxidizing redox state

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conducted mainly on a [Nle 27 ]-hGHRH(1-29)-NH 2 scaffold (in which the native Met 27 is replaced by norleucine), show that individual amino-acid substitutions can increase, reduce, or nearly eliminate activity in specific in-vitro assay systems

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