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Kanetsky, P
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Its function is primarily controlled by Sirtuin 1 (SIRT1) and AMP-activated protein kinase (AMPK) (199)
GST protein
With regard to glutamine metabolism, inhibition of glutamine utilization has likewise been incorporated into the clinical development strategy of metabolic targeting plus immunotherapy. Animal studies have shown that JHU083, a prodrug of the glutamine antagonist 6-diazo-5-oxo-L-norleucine (DON), not only suppresses tumor growth, but also reshapes the transcriptional profile and antigen-presentation/inflammatory cytokine characteristics of tumor-associated macrophages, shifting them from an immunosuppressive tendency toward a functional state more favorable for antitumor immunity (118)
Moreover, several GIP receptor antagonists have also been used to evaluate the therapeutic potential of inhibiting endogenous GIP actions
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