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The transcriptional regulation of these cytoprotective genes is tightly controlled by cis -acting elements, known as antioxidant response elements (ARE), present in the enhancer region 12

Beta cells in the pancreas subsequently increase their production of insulin, further contributing to a high blood insulin level

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Therefore, it is difficult to biosynthesize and accumulate -EC using a fermentation process, such as is generally used in the industrial production of amino acids and peptides