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Allergic Reactions: Though rare, serious allergic responses like bronchospasm or anaphylactic shock can occur

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Large doses of folic acid may also partially mask or worsen vitamin B deficiency by correcting anemia while allowing neurological damage to progress

Perhaps most significantly, not a single serious adverse event was attributed to AOD-9604 administration across the entire trial program

Subcutaneous administration of vitamin B12 is sometimes employed, especially in patients with congenital cobalamin metabolism disorders who require high doses to maintain normal metabolic pathways