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A subsequent meta-analysis of trials (18 to 104 weeks duration) comparing a DPP-4 inhibitor (sitagliptin, saxagliptin, vildagliptin, linagliptin, alogliptin) with placebo (44 trials), a comparator from another class of antidiabetic agents (20 trials), or another DPP-4 inhibitor (three trials) showed a small increased risk of nasopharyngitis compared with placebo (6% vs
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The suboptimal performance of these clinical models has been addressed by more contemporary mutation-enhanced prognostic models [170, 171]
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