peaks during dose escalation, typically mild-moderate Diarrhea -- 10-20%, usually transient Constipation -- 8-15% Vomiting -- 5-15%, more frequent at higher doses Injection site reactions -- 5-10%, mild erythema and pruritus Decreased appetite -- 5-12%, related to mechanism of action Pancreatitis -- rare but monitored (as with all GLP-1/amylin agents) Gallbladder events -- cholelithiasis reported, consistent with rapid weight loss Trial data describes dose titration as central to tolerability -- the 16-week escalation protocol substantially reduced GI adverse events
1,5-AG, 1,5-anhydroglucitol
In contrast, the inner two-thirds of the meniscus lacks a blood supply
The objective of such research is to elucidate the molecular pathways, like the FAK-paxillin axis, that govern the repair of connective tissues
Previous studies had demonstrated that the pigmented proteins from cataractous lenses possess photosensitizing capability and could generate the reactive oxygen species singlet oxygen and superoxide anion when exposed to near ultraviolet (UV) radiation at wavelengths capable of penetrating into the lens
Figured I had nothing to lose at that point