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Constipation affects between 15% and 25% of people taking GLP-1 medications, according to clinical trial data

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Improved insulin sensitivity has been demonstrated in JNK1 knockout mice and increased JNK activity has been reported in obese rodents and humans [56]

a RLM (1D): RLM incubation without fractionation, RLM (2D): RLM incubation with fractionation, 3A4 (1D): CYP3A4 Supersome incubation without fractionation, 3A4 (2D): CYP3A4 Supersome incubation with fractionation, DDA: confirmed by DDA, MRM: confirmed by MRM

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