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J Metab Bariatr Surg 2022

Side effects of GLP-1 agonists commonly include gastrointestinal discomfort, but careful management and consideration of contraindications are essential for safe and effective treatment

The minimum BMI for semaglutide (Wegovy) under FDA labeling is 30 without any additional conditions, or 27 with at least one weight-related comorbidity such as type 2 diabetes, hypertension, or dyslipidemia

For that, see Provns article on how GLP-1 medications work for weight loss

Two research-based comparisons: Retatrutide vs Ozempic How the two compare, by mechanism and trial data

But unlike natural GLP-1, which decays very rapidly (its half-life is just 2 minutes), synthetic GLP-1 receptor agonists are long-acting and remain active in your body for hours or days