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The first step of this pathway involves the production of a highly toxic substance, N-acetyl-p-benzoquinone imine (NAPQI)
FIGURE 1 2.1 Orchestrating the non-immune cells in the tumor microenvironment with peptides 2.1.1 Peptide mediation in cancer-associated fibroblast-induced extracellular matrix remodeling Cancer cells recruit CAFs, which are crucial in shaping the malignant TME
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105,106 ME2 is frequently hemizygously codeleted along with tumor suppressor SMAD4 in human solid tumors including gastric cancer and PDAC
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