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SREBP-1c, sterol regulatory element binding protein-1c

Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression

Evidence classification indicated that one outcome was Class IV (3%), and the rest were NS

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The authors note that this risk was particularly evident among patients also using antidepressants