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There is evidence to suggest that PPA are formed in healthy individuals at therapeutic doses, particularly following repeated doses, suggesting that not all NAPQI is scavenged by glutathione even during therapeutic administration (see Fig

Intratumoral heterogeneity is a hallmark of the disease, showing multiple driving mutations within a single tumor (6) which is reflected in morphological, transcriptional, genetic, epigenetic, functional diversity

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Mousavinejad, E., Ghaffari, M

Given that the primary mechanism underlying liver fibrosis is linked to the activation of stellate cells, this microneedle technology stands out for its ability to safeguard liver cells and potently curb the initiation and advancement of fibrosis [180]