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First, it suggests that the benefits require ongoing treatment rather than producing permanent changes

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Alternatively, lower levels of NO, produced by endothelial nitric oxide synthase (eNOS), play important roles in preventing platelet adhesion to vessel walls during haemostasis 66 , and for both keratinocyte and fibroblast proliferation, motility, and differentiation at the later proliferation and tissue remodelling stages of wound healing 67,68,69

If you develop a rash after starting a new drug, you may be suspicious that your medication is causing this skin reaction