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First-pass metabolism: Anything that survives the gut must pass through the liver, where it may be further processed before reaching the rest of the body

Indeed, others have shown that depletion of gut microbiota in mice results in elongated intestines, reduced transit speed, elevated permeability, and loss of enteric neurons 27

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Neuroscience Letters, 488(1), 7680

Fusobacterium nucleatum metabolically integrates commensals and pathogens in oral biofilms [J]

Even though the body produces glutathione, its levels decrease rapidly due to poor diet, pollution, toxins, medications, stress, immunizations, trauma, infection, radiation, even aging