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GLP-1s help quiet food noise by influencing the release of dopamine in the reward center of the brain

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AMPK activation subsequently inhibits the mTORC pathway (a major regulator of cell growth and proliferation) and promotes cell cycle arrest by stabilizing p53 and the p21/p27 inhibitors (Hardie, 2013

doi: 10.1016/j.cmet.2020.06.011 44 de la Cuesta-ZuluagaJMuellerNTCorrales-AgudeloVVelasquez-MejiaEPCarmonaJAAbadJMet al

It's worth noting that RLS differs from leg cramps or peripheral neuropathy, though symptoms may sometimes overlap

This means it acts on three hormone receptor pathways involved in appetite, fullness, blood sugar control and energy balance