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This hypothesis could explain the increased progression-free survival observed in patients treated with anti-angiogenic drugs combined with chemotherapy as compared to treatment with chemotherapy alone [309]

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Teng Q, Zhu X, Guo Q, Jiang W, Liu J, Meng Q

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Melanotan 1 (afamelanotide) is a modified linear peptide, whereas Melanotan 2 was developed as a cyclic peptide