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Notably, certain plant-derived metabolites activate neuroprotective signaling pathways, such as the MAPK/NF-B system, (Md et al., 2021), and interact with estrogen receptor beta (ER), a known regulator of synaptic plasticity and neuroprotection (Cardona-Gmez et al., 2006)

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Conditions such as systemic lupus erythematosus (SLE) are not included, despite their potential to cause pre-senile dementia through mechanisms like autoimmune antibodies targeting sodium channels on glutamatergic neurons [495]

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