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Discontinuation rates due to adverse events in TRIUMPH-2 were 3.8% (4 mg), 11.6% (9 mg), and 7.7% (12 mg) with retatrutide, compared with 4.9% for placebo

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Plausible mechanisms include weight lossmediated benefit, metabolic regulation and direct antiinflammatory effects, but current data are limited by small samples and uncontrolled designs

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CJC-1295, a GHRH analog, extends the duration of growth hormone release