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It is considered a potential co-biomarker that links metabolic, neuroendocrine, and reproductive health, providing important clues for understanding the common pathogenesis of these diseases and developing novel therapeutic strategies

Regarding treatment strategies, it is suggested that the marked decrease in GPx1 expression may be the major mechanism of tumor sensitization to anthracyclines [93] and that GPx1 can partially inhibit doxorubicin-induced cell death-related signaling in breast cancer by interfering with the activation of the sphingomyelin-ceramide pathway [85]