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Notably, these transgenic mice presented minimal or no changes in autophagy in the liver, lung, or spleen, 221 suggesting that autophagy disruption is closely linked to AP progression

Margulies KB, Hernandez AF, Redfield MM, Givertz MM, Oliveira GH, Cole R, et al

As a prominent example, in Teva Pharma

Science 366 (6467), 827832

The activity of BRAF kinase is regulated by the interaction formed between A-loop and P-loop, thus mutations in either A-loop or P-loop disrupt the interaction and cause hyperactivation of the kinase (93, 95)