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Monitor baseline GH, IGF-1, and sex hormones before and during treatment

The current regulatory framework requires demonstration of clinically meaningful weight losstypically defined as at least 5% greater weight reduction than placeboalong with comprehensive safety evaluation that addresses both short-term tolerability and long-term cardiovascular and cancer risks [23]

Low-grade chronic inflammation is now known to be a major contributor to a myriad of conditions, including cancer, obesity and diabetes (Underwerth)

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