Zheng J, Xie Y, Ren L, Qi L, Wu L, Pan X, et al
As of 2025, the shortage is resolved, but patients and prescribers may still see intermittent disruptions in supply
For example, in 2023, the European Medicines Agency began investigating over 150 reports of suicidal ideation and other psychiatric symptoms linked to GLP-1 receptor agonists, including Ozempic and Wegovy
Plus, rapid weight loss associated with GLP-1s may contribute to gallstone formation, while the emotional and psychological impacts of sudden changes in appetite and body composition remain unstudied
GLP-1 treatments, such as liraglutide and semaglutide, work by curbing appetite and slowing digestion
The side effect profile is dose-dependent, predictable, and in most cases manageable with proper preparation