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[41] reported that 7 days of HC feeding (45% increase in total energy) reduced insulin-stimulated eNOS Ser-phosphorylation in terminal arterioles of skeletal muscle and reduced glucose clearance in healthy participants

In participants with overweight/obesity without diabetes, the highest dose of retatrutide produced 24.2% reduction in body weight after 48 weeks [75]

Tari AM, Andreeff M , Kleine HD, Lopez-Berestein G