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Based on evidence from the Semaglutide Treatment Effect in People with Obesity (STEP) 1 randomised controlled trial, the guidance recommends that semaglutide should be considered in adults with at least one weight-related condition and a body mass index (BMI) of at least 35

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However, this review also critically evaluates alternative explanations for the translational gap, including limited central nervous system penetration, insufficient pharmacodynamic target engagement, a mismatch between the drugs metabolic mechanisms and the amyloid-driven pathology of established AD, and the inherent limitations of preclinical models

doi:10.1007/978-3-030-28929-4_3