There are no quality studies to suggest otherwise, and people risk rectal burns and caffeine overdose, alongside other complications of enemas
Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats
Am J Physiol Gastrointest Liver Physiol 2014, 307: G397G409
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They also clarified in another clinical study that supplements with glycine (1.33 mmol/kg/day) and N-acetylcysteine (0.81 mmol/kg/day) for 24 weeks corrected erythrocyte-GSH deficiency and alleviated oxidative stress and mitochondrial dysfunction in elderly individuals [110]
The break trial represents valuable experiment for any GHK-Cu user completing 6+ month treatment course - discontinuing for 2-3 months reveals how well benefits persist, helps determine whether cycling or continuous use better suits individual biology, provides psychological break from rigid routine, and offers cost savings period while assessing necessity of ongoing application