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First description in humans of the ability of SGLT2 inhibitors to attenuate glomerular hyperfiltration, likely by affecting tubuloglomerular feedback mechanisms

Together, these actions help maintain a healthy weight and regulate your blood glucose levels

Endocrinologists have cautioned that Zepbound and similar drugs are intended to be taken indefinitely

10.1016/j.clinbiochem.2017.03.008 89

Continued research led to the first GLP-1 drugs approved for weight loss in people with obesity or overweight: liraglutide or Saxenda in 2014, semaglutide as Wagovy in 2021 and tirzepatide as Zepbound in 2023

Inform your eye doctor about any changes to your semaglutide dose, your current hemoglobin A1c level, and other diabetes medications you take