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Indeed, we observed an increase in xanthine dehydrogenase (XDH) mRNA expression, the enzyme responsible for transforming purine bases into uric acid 50 (Fig

Native IGF-1's extremely short free half-life of 12-15 minutes is primarily determined by rapid IGFBP capture (which removes it from the free pool), renal filtration of the small 7.6 kDa protein, and IGF-1R-mediated endocytosis and lysosomal degradation

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