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This is true of Mounjaro for constipation, based on clinical trials: Interestingly, however, this doesnt seem to be the case for constipation with Zepbound in clinical trials: No matter the likelihood of experiencing tirzepatide constipation, the side effect tends to get better with time and thats true for both Zepbound and Mounjaro Why does tirzepatide cause constipation

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GLP-1/GCPR dual agonist (Amercian Diabetes Association, American Physiological Society) , ,

Trying to force them out (through certain "flush" remedies) can be dangerous

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